• Jennifer Jo Cobb, race car driver and team owner
• Stephanie D. Davis, U. S. District court judge and U. S. Court of Appeals judge
• Maurice Greene, Gold-medal winning U.S. Olympic track and field sprinter
• Janelle Monáe, Grammy-nominated singer and actress best known for Hidden Figures and Moonlight
• Damian Rolls, former MLB player and former hitting coach of the Kansas City T-Bones
• Sam Simmons, former NFL player
• Trai Byers, Actor

• Bernard Harvey ("Harv"), music producer, songwriter, and music director
• Mark Haynes, former NFL player who played in 3 Pro Bowls (1982, 1983, 1984) and 3 Super Bowls (1987, 1988, 1990)
• Janet Murguia, current president and CEO of UnidosUS, the US's largest Latino nonprofit advocacy organization in Washington, DC
• Mary H. Murguia, current Chief Judge of the United States Court of Appeals for the Ninth Circuit in Phoenix, AZ 

• Randy Lopez, becomes first Hispanic elected to the Board of Education 

Sumner High School

• William Foster, Former Member of the National Council of Arts, President of the American Bandmasters Association, Director of the Marching 100 at Florida A&M University, National Association for Distinguished Band Conductors Hall of Fame Inductee, and board member of the John Phillips Sousa Foundation.
• Fernando J. Gaitan Jr., (class of 1966), senior United States district judge of the United States District Court for the Western District of Missouri
• Paul Graham (class of 1969) former head basketball coach at Washington State Cougars men's basketball
• Leonard Gray (Class of 1969), former NBA player for the Seattle SuperSonics
• Harold Hunter (Class of 1944), first African American to sign a contract with a National Basketball Association (NBA) team[19]
• Delano Lewis, (class of 1956), attorney, businessman, diplomat, and United States Ambassador to South Africa from 1999 to 2001.
• John McClendon, first African American head coach in any professional sport and enshrined in the Naismith Basketball Hall of Fame and National Collegiate Basketball Hall of Fame
• Judge Cordell D. Meeks, the first Black District Court Judge of Kansas
• Charles Wilber "Bullet" Rogan (Class of 1908), pitcher, hitter, and later manager for the Kansas City Monarchs, inductee to the Baseball Hall of Fame.[20]

• Wendell Gaskin, former and USA Track and Field star
• Paul J. Morrison, former Kansas Attorney General
• Le'Tristan Pledger, former Texas Tech University and USTFCCA All-American track and field star[21]
• Darrell Stuckey, former NFL player with San Diego Chargers and current Director of Football Relations at University of Kansas football
• Earl Watson, former NBA player and head coach of Phoenix Suns and current assistant coach of Toronto Raptors
• Nathan Louis Jackson, Screenwriter [1]
• Freddie Williams II, American comic book writer and artist with DC comics on the comic series Robin and on the Eisner Award-winning series Seven Soldiers: Mister Miracle. He has since gone on to work on several crossover series including Batman/Teenage Mutant Ninja Turtles, Batman/Teenage Mutant Ninja Turtles II, He-Man/ThunderCats and Injustice vs. Masters of the Universe. [2]

• Boots Adams, former president of Phillips Petroleum Company
• Virginia Aderholdt, cryptanalyst and Japanese translator at Arlington Hall, who decrypted the intercepted Japanese surrender message, August 14, 1945.
• Lucius Allen, former UCLA & NBA player, third pick of 1969 NBA draft
• Edward Asner, actor, Elf, Up, The Mary Tyler Moore Show, Lou Grant, won seven Primetime Emmy Awards, most of any male actor in history
• Lyron Cobbins, former NFL and Notre Dame Fighting Irish All-American linebacker
• Larry Comley, former NBA professional basketball player
• Lucien Conein, intelligence officer for the Central Intelligence Agency[15]
• Larry Drew, former head coach of the NBA Atlanta Hawks; former NBA player for multiple teams after playing in college for Missouri Tigers
• Nolen Ellison, University of Kansas basketball star and pioneering community college educator
• Ray Evans, former NFL player
• Reggie Jones, former NFL player and NCAA track & Field relay champion
• Steve Renko, former MLB player (Montreal Expos, Chicago Cubs, Chicago White Sox, Oakland Athletics, Boston Red Sox, California Angels, Kansas City Royals)
• Pierre Russell, former Kansas Jayhawks and professional basketball player
• Skip Thomas, former NFL cornerback for Oakland Raiders after playing in college for USC
• Spencer Thomas, former NFL player
• Calvin Thompson, former Kansas Jayhawks and professional basketball player
• Dee Wallace, actress, E.T.,The Howling, Cujo
• Cheryl Womack, entrepreneur
• Ida McBether, Jazz Singer